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Supplementary material The Supplementary Material for this article can be found online at: Glossary ACO acyl coenzyme A oxidase AMPK adenosine monophosphate-activated protein kinase ANCOVA analysis of covariance aP2 adipose-specific fatty acid-binding protein ARR absolute risk reduction BAT brown adipose tissue BMI body mass index BSH bile salt hydrolase CFU colony-forming unit Chol cholesterol ChREBP carbohydrate-responsive element-binding protein CI confidence interval CPT-Ia carnitine palmitoyltransferase Ia ELISA enzyme-linked immunosorbent assay FBG fasting blood glucose FBS fasting blood sugar FBP2 fructose-1,6-bisphosphatase isozyme 2 FFAs free fatty acids FFAR3 free fatty acid receptor 3 FFAR2 free fatty acid receptor 2 FIAF fasting-induced adipose factor FOS fructo-oligosaccharide FXR farnesoid X receptor GLP-1 glucagon-like peptide-1 GLP-2 glucagon-like peptide-2 GPR41 G protein-coupled receptor 41 GPR43 G protein-coupled receptor 43 GPCRs G protein-coupled receptors HC hip circumference HDL-C high-density lipoprotein-cholesterol HMG-CoA hydroxymethylglutaryl CoA reductase HOMA-IR homeostatic model assessment of insulin resistance HSL hormone-sensitive lipase IGF-1 insulin-like growth factor 1 IPAQ-SF International Physical Activity Questionnaire-Short Form ITT intention-to-treat LDL-C low-density lipoprotein-cholesterol LPL lipoprotein lipase LPS lipopolysaccharide METs metabolic equivalent of tasks NF-B nuclear factor kappa B NHLBI National Heart, Lung, and Blood Institute NNT number needed to treat NSAIDs non-steroidal anti-inflammatory drugs OTC over the counter PC percent of changes PCK1 phosphoenolpyruvate carboxykinase PDHC pyruvate dehydrogenase complex PPAR- peroxisome proliferator-activated receptor-gamma PGC-1 peroxisome proliferator-activated receptor-gamma coactivator 1 PYY peptide YY QUICKI quantitative insulin sensitivity check index RAS random allocation software RCT randomized clinical trial REE resting energy expenditure SCFAs short-chain fatty acids SD standard deviation SREBP sterol regulatory element-binding protein TC total cholesterol TG triglyceride TGR5 Takeda G protein-coupled bile acid receptor 5 TLR-LPS Toll-like receptor-LPS TLR4 Toll-like receptor 4 UCP-1 uncoupling protein-1 VLDL very low-density lipoprotein WAT white adipose tissue WC waist circumference WHR waist to hip ratio References 1 BleichSNCutlerDMurrayCAdamsA

Some research indicates that these drugs may help protect joints and reduce bone erosion, potentially preserving mobility and quality of life

Griffith RS, Walsh DE, Myrmel KH, et al

The odds of developing knee osteoarthritis increase nearly sevenfold with severe obesity

For instance, the National Service Framework (NSF) program is improving services by setting national standards to drive up service quality and tackle variations in care